Journal
SEMINARS IN IMMUNOLOGY
Volume 24, Issue 1, Pages 3-8Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2011.11.006
Keywords
Euprymna; Vibrio fischeri; MAMP; Quorum sensing; Symbiosis; Bioluminescence
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Funding
- NIH [RO1-AI50661, RR R01-12294]
- NSF [IOS 0841507]
- WM Keck Foundation
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [841507] Funding Source: National Science Foundation
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Recent research on a wide variety of systems has demonstrated that animals generally coevolve with their microbial symbionts. Although such relationships are most often established anew each generation, the partners associate with fidelity, i.e., they form exclusive alliances within the context of rich communities of non-symbiotic environmental microbes. The mechanisms by which this exclusivity is achieved and maintained remain largely unknown. Studies of the model symbiosis between the Hawaiian squid Euprymna scolopes and the marine luminous bacterium Vibrio fischeri provide evidence that the interplay between evolutionarily conserved features of the innate immune system, most notably MAMP/PRR interactions, and a specific feature of this association, i.e., luminescence, are critical for development and maintenance of this association. As such, in this partnership and perhaps others, symbiotic exclusivity is mediated by the synergism between a general animal-microbe 'language' and a 'secret language' that is decipherable only by the specific partners involved. (C) 2011 Elsevier Ltd. All rights reserved.
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