Journal
SEMINARS IN IMMUNOLOGY
Volume 23, Issue 2, Pages 99-105Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2011.01.008
Keywords
Th17 cells; Aryl hydrocarbon receptor; Inflammation; Innate immunity; Adaptive immunity
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Funding
- Medical Research Council UK
- ERC
- Biotechnology and Biological Sciences Research Council [BBS/E/B/0000S042] Funding Source: researchfish
- BBSRC [BBS/E/B/0000S042] Funding Source: UKRI
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The aryl hydrocarbon receptor (AhR), subject of intensive research over three decades by the pharmacology/toxicology field has recently made its entry into mainstream immunology research and is set to continue to intrigue with ever more complex modes of modulating immune responses. The discovery of high and selective AhR expression on Th17 cells [1-3] and its role in induction of the cytokine IL-22 [1] attributed new immunological functions to this transcription factor and stimulated further research into physiological functions of the AhR in the immune system. A number of recent reviews [4-11] have highlighted potential new avenues of research. This review addresses recent new insight into physiological roles of AhR in the immune system. (C) 2011 Elsevier Ltd. All rights reserved.
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