Journal
SEMINARS IN IMMUNOLOGY
Volume 23, Issue 1, Pages 28-41Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2011.01.006
Keywords
Skin DCs; Homeostasis; Regulatory DCs; Chronic inflammation; Psoriasis
Categories
Funding
- Wellcome Trust [GR078173MA]
- NIH [RO1AR040065]
- NIHR Comprehensive Biomedical Research Centre Guy's and St. Thomas' Hospital and King's College London
- Medical Research Council UK [G0601387]
- Dunhill Medical Trust
- St. John's Institute of Dermatology
- Overseas Research Students Awards Scheme (ORSAS)
- Medical Research Council [G0601387, G0600698B] Funding Source: researchfish
- MRC [G0601387] Funding Source: UKRI
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The skin immune system harbors a complex network of dendritic cells (DCs). Recent studies highlight a diverse functional specialization of skin DC subsets. In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms to ensure the maintenance of immune homeostasis, as well as in pathogenesis of chronic inflammation in the skin when excessive immune responses are initiated and unrestrained. Harnessing DCs by directly targeting DC-derived molecules or selectively modulate DC subsets is a convincing strategy to tackle inflammatory skin diseases. In this review we discuss recent advances underlining the functional specialization of skin DCs and discuss the potential implication for future DC-based therapeutic strategies. (C) 2011 Elsevier Ltd. All rights reserved.
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