Journal
SEMINARS IN IMMUNOLOGY
Volume 23, Issue 6, Pages 431-437Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2011.06.002
Keywords
Regulatory T cells; Obesity; Type 2 diabetes; Inflammation; Adipose tissue
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Funding
- National Science Foundation
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Foxp3+CD4+ regulatory T (T-reg) cells are a key population in controlling the immune response. Recently, their roles have been expanded to broader, non-immune, contexts, in particular the metabolic consequences downstream of obesity-induced inflammation, e.g. type-2 diabetes and cardiovascular disease. This review highlights the major innate and adaptive immune cell subsets contributing to adipose-tissue inflammation, the key role played by fat-resident T-regs, and the potential of T-reg-based therapies for treatment of the metabolic syndrome. (C) 2011 Elsevier Ltd. All rights reserved.
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