Journal
SEMINARS IN IMMUNOLOGY
Volume 22, Issue 4, Pages 199-206Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2010.04.004
Keywords
Human gamma delta T cells; T cell receptor; Co-stimulation; Signal transduction; Functions
Categories
Funding
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Agence Nationale de la Recherche (ANR) [A05118GS]
- Association pour la Recherche sur le Cancer [4953]
- Institut National du Cancer (INCa) [V9V2THER]
- Commission of the European Union [LSHP-CT-2003-503367]
- Cancer Immunotherapy [E06005NP/EEA06004GNP]
Ask authors/readers for more resources
Human V gamma 9V delta 2 T cells, a major innate-like peripheral T cell subset, are thought to play in vivo a key role in innate and adaptive immune responses to infection agents and tumors. V gamma 9V delta 2 T cell activation is tightly regulated by a variety of activating or inhibitory receptors which are specific for constitutively expressed or stress-modulated ligands. However, the mechanisms and signal transduction pathways regulating their broad effector functions, such as cytotoxicity and cytokine responses, remain poorly understood. Here we provide an updated overview of the activation modalities of V gamma 9V delta 2 T cells by highlighting the respective role played by T cell receptor (TCR) versus non-TCR stimuli, and focus on recent studies showing how V gamma 9V delta 2 T cells integrate the numerous activating and inhibitory signals and translate them into a particular effector and biological function. A better understanding of these critical issues should help optimize immunotherapeutic approaches targeting V gamma 9V delta 2 T cells. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available