Journal
SEMINARS IN IMMUNOLOGY
Volume 22, Issue 4, Pages 222-227Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2010.04.003
Keywords
T cell development; T cell lineage commitment; T cell receptor; gamma delta T cells; WNT signaling
Categories
Funding
- NIH/NCI [CA100382]
Ask authors/readers for more resources
The mechanism of T cell precursor commitment to the gamma delta or alpha beta T cell lineage remains unclear. While TCR signal strength has emerged as a key factor in lineage commitment based on TCR transgenic models, the entire TCR repertoire may not possess the same discriminatory power. A counterbalance to the TCR as the lineage determinant is the pre-existing heterogeneity in gene expression among precursors, which suggests that single precursors are unlikely to respond homogeneously to a given instructive signal. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available