Journal
SEMINARS IN IMMUNOLOGY
Volume 21, Issue 2, Pages 84-91Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2009.02.003
Keywords
T lymphocytes; T cell receptors; Signal transduction; Transcription factors; Innate immunity
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Funding
- NIH [A142092]
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Memory T cells exhibit low activation thresholds and rapid effector responses following antigen stimulation, contrasting naive T cells with high activation thresholds and no effector responses. Signaling mechanisms for the distinct properties of naive and memory T cells remain poorly understood. Here, 1 will discuss new results on signal transduction in naive and memory T cells that suggest proximal control of activation threshold and a distinct biochemical pathway to rapid recall. The signaling and transcriptional pathways controlling immediate effector function in memory T cells closely resemble pathways for rapid effector cytokine production in innate immune cells, suggesting memory T cells use innate pathways for efficacious responses. (C) 2009 Elsevier Ltd. All rights reserved.
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