Journal
SEMINARS IN IMMUNOLOGY
Volume 21, Issue 4, Pages 223-232Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2009.05.009
Keywords
Mitochondria; Innate immunity; Viruses; Bacteria; Microbial pathogenesis; RIG-I; MAVS; NLRX1
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Funding
- Canadian Institutes of Health Research (CIHR)
- Crohn's and Colitis Foundation of Canada
- Burroughs Wellcome Fund
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Mitochondria have been long recognized for their key role in the modulation of cell death pathways. Thus, it is therefore not surprising that this organelle represents a recurrent target for pathogenic microbes, aiming to manipulate the fate of the infected host cell. More recently, mitochondria have been shown to serve as a crucial platform for innate immune signaling, as illustrated by the identification of MAVS (also known as IPS-1, VISA and Cardif), NLRX1 and STING as mitochondrial proteins. This review discusses the tight interplay between microbial infection, innate immune signaling and mitochondria. (C) 2009 Elsevier Ltd. All rights reserved.
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