Journal
SEMINARS IN IMMUNOLOGY
Volume 20, Issue 4, Pages 228-235Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2008.08.003
Keywords
cell fate determination; lineage restriction; transcription factor antagonism; myeloid and lymphoid lineages; macrophages; neutrophils; B and T lymphocytes
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
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Considerable progress is being achieved in the analysis of gene regulatory networks that direct cell fate decisions within the hematopoietic system. In addition to transcription factors that are pivotal for cell fate specification and commitment, recent evidence suggests the involvement of microRNAs. In this review we attempt to integrate these two types of regulatory components into circuits that dictate cell fate choices leading to the generation of innate as well as adaptive immune cells. The developmental circuits are placed in the context of a revised scheme for hematopoiesis that suggests that both the innate (myeloid) and adaptive (lymphoid) lineages of the immune system arise from a common progenitor. (C) 2008 Elsevier Ltd. All rights reserved.
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