Journal
SEMINARS IN IMMUNOLOGY
Volume 20, Issue 1, Pages 67-82Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2007.12.006
Keywords
B cells; effector memory; central memory; marginal zone; homeostasis
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Memory B cells are more heterogeneous than previously thought. Given that B cells play powerful antibody-independent effector functions, it seems reasonable to assume division of labor between distinct memory B cells subpopulations in both protective and pathogenic immune responses. Here we review the information emerging regarding the heterogeneity of human memory B cells. A better understanding of this topic should greatly improve our ability to target specific B cell subsets either in vaccine responses or in autoimmune diseases and organ rejection among other pathological conditions where B cells play central pathogenic roles. (C) 2007 Elsevier Ltd. All rights reserved.
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