Journal
SEMINARS IN IMMUNOLOGY
Volume 20, Issue 1, Pages 14-25Publisher
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2007.12.001
Keywords
antibody response; lymphocyte; FDC; germinal center; lymph node
Categories
Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIAID NIH HHS [R01 AI045073, R37 AI040098-08, R01 AI045073-09, R37 AI040098-12, R37 AI040098-10, R37 AI040098, R37 AI040098-11, R37 AI040098-06, R01 AI045073-07, R37 AI040098-09, R37 AI040098-07, R01 AI045073-10, R01 AI045073-06, R01 AI045073-08] Funding Source: Medline
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Follicular dendritic cells (FDCs) were identified decades ago by their ability to retain immune complexes and more recent findings indicate that they are a source of B cell attractants and trophic factors. New imaging studies have shown that B cells closely associate with their dendritic processes during migration. Here we will review the properties of these specialized follicular stromal cells and provide an update on the requirements for their maturation into phenotypically distinct cells within germinal center light and dark zones. We will then discuss current understanding of how they help support the B cell immune response. (C) 2008 Elsevier Ltd. All rights reserved.
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