4.5 Review

The role of collagen deposition in depleting CD4+T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche

Journal

SEMINARS IN IMMUNOLOGY
Volume 20, Issue 3, Pages 181-186

Publisher

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2008.04.002

Keywords

HIV pathogenesis; lymphatic tissues; fibrosis; immune reconstitution; naive CD4 cells

Categories

Funding

  1. NCI NIH HHS [N01CO12400, N01-CO-12400, P130-CA79458-01] Funding Source: Medline
  2. NCRR NIH HHS [M01 RR00400, M01 RR000400] Funding Source: Medline
  3. NIAID NIH HHS [R01 AI054232-01A2, AI056997, R01 AI056997, R56 AI054232-06A1, R56 AI054232, R01 AI048484, R37 AI 28246, 2U01 AI041535, R01 AI48484, AI07421, R01 AI054232, R01 AI54232-01A2, R37 AI028246, T32 AI007421] Funding Source: Medline
  4. NIDCR NIH HHS [1R01DE12934-01] Funding Source: Medline

Ask authors/readers for more resources

The hallmark of HIV/SIV infections is the progressive depletion of CD4+ T cells that ultimately renders the host incapable of defending against AIDS defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4+ T cell loss, we review here the growing evidence that fibrotic 'scarring' and consequent damage to the lymphatic tissue niche contributes to CD4+ T cell decline and limits CD4+ T cell re-population with retroviral therapy. (c) 2008 Elsevier Ltd. All rights reserved.

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