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The lymph node in HIV pathogenesis

Journal

SEMINARS IN IMMUNOLOGY
Volume 20, Issue 3, Pages 187-195

Publisher

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2008.06.001

Keywords

CD38; cell cycle; HIV; immune activation; lymph node; microbial translocation; toll like receptors

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Funding

  1. Case Western Reserve University

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Since the earliest days of the AIDS epidemic, clinicians and researchers have recognized the importance of lymphoid tissue both in the clinical manifestations of disease and in its pathogenesis. Generalized lymphadenopathy was one of the earliest harbingers of AIDS in the United States and over the past 27 years an increasing body of evidence has implicated the lymphoid organs as central to the pathogenesis of immune deficiency in chronic HIV-1 infection. In this essay, we will review some of the data that have been accumulated and propose a testable model that may reconcile them. (c) 2008 Elsevier Ltd. All rights reserved.

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