Journal
SEMINARS IN IMMUNOLOGY
Volume 20, Issue 3, Pages 159-163Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2008.02.002
Keywords
HIV; AIDS; CD4 memory; lymphoid tissue organization
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Funding
- Medical Research Council, UK
- [Wellcome Trust]
- National Research Foundation of Korea [핵C6A3501] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Lymphoid tissue inducer cells (LTi) are known for their role in embryonic lymphoid tissue development. We have identified LTi in adult tissues including spleen and thymus, and provide evidence here for their presence in the submucosa of the intestine. From these observations it is clear that LTi play multiple roles in the adaptive immune system, notably the ability to recruit and sustain primed CD4 T cells in environments where they provide help to other cells. We speculate that their human equivalents could be potential targets for HIV infection and their destruction explains the pattern of loss of CD4 T cells. (c) 2008 Elsevier Ltd. All rights reserved.
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