Journal
SEMINARS IN HEMATOLOGY
Volume 51, Issue 3, Pages 168-176Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.seminhematol.2014.05.002
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Funding
- Associazione Italiana Ricerca Cancro (AIRC) [IG-13227, MFAG-10327]
- Progetto Ricerca Finalizzata I.R.C.C.S. [RF-2009-1469205, RF-2010-2307262]
- Progetto Giovani Ricercatori [GR-2009-1475467]
- Ministero della Salute, Rome, Italy
- Fondazione Internazionale di Ricerca in Medicina Sperimentale (FIRMS) Turin, Italy
- Associazione Italiana contro le Leucemie, linfomi e mielomi (AIL), Venezia Section, Pramaggiore Group, Italy
- Ricerca Scientifica Applicata, Regione Friuli Venezia Giulia (Linfonet Project), Trieste, Italy
- 5 x 1000 Intramural Program, Centro di Riferimento Oncologico, Aviano, Italy
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Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by the accumulation/expansion of a clonal population of neoplastic cells with the morphologic appearance of small mature B lymphocytes in blood, bone marrow, and lymphoid organs. A combination of genetic lesions is primarily responsible for the first step(s) of neoplastic transformation, along with microenvironmental signals, which concurrently operate by enhancing proliferation and/or inhibiting apoptosis. In this context, CD49d is known to play a pivotal role in mediating both cell-cell and cell-matrix interactions in CLL-involved tissues, eventually delivering pro-survival signals and protecting CLL cells from drug-induced damages. In the present review, we address, in detail, CD49d activities in the CLL microenvironment, CD49d functional and physical interactions with other microenvironmental receptors (including CD38 and B-cell receptor), and the relationship of CD49d expression with specific cytogenetic features in CLL. (C) 2014 Elsevier Inc. All rights reserved.
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