Journal
SEMINARS IN HEMATOLOGY
Volume 50, Issue 2, Pages 131-144Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.seminhematol.2013.03.026
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Funding
- NCI NIH HHS [P01 CA094237, P30 CA125123, P50 CA126752] Funding Source: Medline
- NHLBI NIH HHS [T32 HL092332] Funding Source: Medline
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Mouse models of transplantation have been indispensable to the development of bone marrow transplantation (BMT). Their role in the generation of basic science knowledge is invaluable and is subject to discussion below. However, this article focuses on the direct role and relevance of mouse models towards the clinical development and advances in BMT and adoptive T-cell therapy for human diseases. The authors aim to present a thoughtful perspective on the pros and cons of mouse models while noting that despite imperfections these models are obligatory for the development of science-based medicine. Semin Hematol 50:131-144. (C) 2013 Published by Elsevier Inc.
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