Journal
SEMINARS IN HEMATOLOGY
Volume 49, Issue 3, Pages 223-227Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.seminhematol.2012.04.006
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Funding
- NCI NIH HHS [P01 CA078378, P50 CA100707, R01 CA050947] Funding Source: Medline
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The ubiquitin-proteasome pathway (UPP) is a major protein degradation system that maintains homeostasis of intracellular proteins, involved in DNA repair, cell cycle regulation, cell proliferation, and drug resistance. Since numerous proteins are processed by proteasomes, their inhibition triggers dramatic disruption of protein homeostasis. Consequently, accumulation of polyubiquitinated proteins triggers different types of cellular stress responses, followed by growth arrest and cytotoxicity. Importantly, multiple myeloma (MM) cells are considered to have lower threshold against these stresses than other cell types, which makes these cells sensitive to proteasome inhibitors. Semin Hematol 49:223-227. (C) 2012 Elsevier Inc. All rights reserved.
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