Journal
SEMINARS IN HEMATOLOGY
Volume 49, Issue 2, Pages 182-191Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.seminhematol.2012.01.001
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Treatment of the hypereosinophilic syndrome (HES) has advanced rapidly and prevention of end organ damage previously associated with the disorders is now possible in most patients who have had a timely diagnosis. Tried and true medications such as prednisone, hydroxyurea, and interferon-alpha (IFN-a alpha) continue to play a valuable role in treating HES and their cost is modest. Newer medications included pegylated forms of IFN-a alpha and IFN-alpha 2b, first- and second-generation tyrosine kinase inhibitors (imatinib mesylate, nilotinib), and monoclonal antibodies to interleukin (IL)-5 and CD52. The combination of better understanding of HES and better medications now provide the clinician with an improved ability to control unregulated proliferation of eosinophils. Semin Hematol 49:182-191. (C) 2012 Elsevier Inc. All rights reserved.
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