Clinical Trials for Human T-Cell Lymphotropic Virus Type I-Associated Peripheral T-Cell Lymphoma in Japan

The most common subtype of T-/natural killer (NK) cell lymphoma in japan is adult T-cell leukemia-lymphoma (ATL), which is associated with the human T-cell lymphotropic virus type I (HTLV-I). The investigators in Japan have conducted several clinical trials on multi-agent chemotherapy and stem cell transplantation for patients with AIL. They have also initiated several new clinical trials with a number of agents: an anti-CCR4 antibody, KW-0761; forodesine, a purine nucleoside phosphorylase inhibitor; and lenalidomide, an immunomodulatory agent. Clinical trials with pralatrexate, a folate analog, and denileukin diftitox, an immunoconjugate, are under discussion for patients with ATL and peripheral T-cell lymphoma (PTCL). Semin Hematol 47:S5-S7. (C) 2010 Elsevier Inc. All rights reserved.