Journal
SEMINARS IN FETAL & NEONATAL MEDICINE
Volume 18, Issue 1, Pages 42-47Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.siny.2012.10.001
Keywords
Loco-regional anesthesia; Morphine; Neuro-apoptosis; Newborn; Pain; Paracetamol
Categories
Funding
- Fund for Scientific Research, Flanders (Belgium) (F.W.O. Vlaanderen)
- Fundamental Clinical Investigatorship [1800209N]
- NIH [R01HD060543, K24DA027992, R01HD048689, U54HD071601]
- FP7 grant TINN [223614]
- FP7 grant TINN2 [260908]
- FP7 grant NEUROSIS [223060]
Ask authors/readers for more resources
Inadequate management of pain in early human life contributes to impaired neurodevelopmental outcome and alters pain thresholds, pain or stress-related behavior and physiological responses. However, there are also emerging animal experimental data on the impact of exposure to analgo-sedatives on the incidence and extent of neuro-apoptosis. Since this association has also been suggested in humans, the pharmacological treatment of neonatal pain is in search of a new equipoise since these 'conflicting' observations are the main drivers to further reconsider our current treatment regimens. This review focuses on new data concerning clinical pharmacology of morphine, followed by data on more recently introduced opioids like remifentanil and tramadol, locoregional anesthesia and minimally invasive techniques in neonates, and finally with data on intravenous paracetamol. Since the available data are still incomplete, priorities for both clinical management and future research will be proposed. (c) 2012 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available