Journal
SEMINARS IN FETAL & NEONATAL MEDICINE
Volume 17, Issue 2, Pages 92-98Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.siny.2012.01.003
Keywords
Adult; Fetal; Intrauterine growth restriction; Lung; Lung function; Lung maturation
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Funding
- Food Standards Agency UK
- British Lung Foundation
- SPARKS (Sport Aiding medical Research for Kids)
- Wellcome Trust Clinical Research Facility Southampton
- NIHR Respiratory Biomedical Research Unit Southampton
- Medical Research Council Epidemiology Resource Centre
- University of Southampton
- National Health and Medical Research Council, Australia [634519, 1010575, 1010665]
- Viertel Senior Medical Research Fellowship
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Epidemiological studies demonstrate that in-utero growth restriction and low birth weight are associated with impaired lung function and increased respiratory morbidity from infancy, throughout childhood and into adulthood. Chronic restriction of nutrients and/or oxygen during late pregnancy causes abnormalities in the airways and lungs of offspring, including smaller numbers of enlarged alveoli with thicker septal walls and basement membranes. The structural abnormalities and impaired lung function seen soon after birth persist or even progress with age. These changes are likely to cause lung symptomology through life and hasten lung aging. (C) 2012 Elsevier Ltd. All rights reserved.
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