Journal
SEMINARS IN FETAL & NEONATAL MEDICINE
Volume 14, Issue 4, Pages 209-217Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.siny.2008.11.008
Keywords
Congenital varicella syndrome; Diagnosis; Fetal infection; Herpes zoster; Pregnancy; Vaccination; Varicella
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Varicella (chickenpox) in pregnancy is unusual because most women of childbearing age are immune. It can, however, cause significant morbidity for the pregnant woman and in rare cases cause congenital varicella syndrome. The incidence of congenital varicella syndrome after maternal varicella during the first two trimesters is <1% across multiple cohort Studies. Maternal infection in the third trimester is not associated with congenital varicella syndrome, but the infant may develop herpes zoster during the first one or two years. Maternal infection just before or after delivery presents a high risk for disseminated varicella in the infant. Serious infection call be prevented with passive antibody prophylaxis and antiviral therapy. Maternal herpes zoster does not result in adverse fetal or neonatal Outcomes. (C) 2008 Elsevier Ltd. All rights reserved.
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