Journal
SEMINARS IN FETAL & NEONATAL MEDICINE
Volume 13, Issue 2, Pages 63-68Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.siny.2007.12.012
Keywords
fetal RHD status; non-invasive prenatal; diagnosis; cell-free fetal DNA
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RhD blood group incompatibility between a pregnant woman and her fetus can result in maternal alloimmunization and consequent haemolytic disease of the newborn (HDN) in subsequent pregnancies. The D-negative blood group is found in 15% of whites, 3-5% of black Africans, and is rare in Asians. Recent technological advances in non-invasive prenatal determination of the fetal RHD status using cell-free fetal DNA (cffDNA) have opened new avenues for the management of D-negative pregnant women. In this review applications for the high risk women, as well as potential for routine screening wilt be discussed. The use of non-invasive prenatal diagnosis and the management of other blood incompatibilities wilt also be discussed. (c) 2007 Elsevier Ltd. All rights reserved.
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