Journal
SEMINARS IN DIALYSIS
Volume 22, Issue 4, Pages 428-432Publisher
WILEY
DOI: 10.1111/j.1525-139X.2009.00594.x
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It is obvious that retention of uremic toxins leads to endothelial dysfunction, which in turn initiates proliferation of vascular smooth muscle cells. Yet, the entity of the cascade of pathomechanisms has not sufficiently been elucidated. Endothelial dysfunction inevitably and irreversibly leads to progressive cardiovascular dysfunction and thereby represents the beginning of a life-limiting cascade. This review highlights important findings in this field.
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