Journal
SEMINARS IN DIAGNOSTIC PATHOLOGY
Volume 29, Issue 2, Pages 67-71Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.semdp.2011.09.001
Keywords
Penile cancer; Squamous cell carcinoma; HPV infection; Warty carcinoma; Basaloid carcinoma; Prognostic factors
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Emerging evidence suggests that penile cancer follows 2 etiologic pathways, I related to human papillomavirus (HPV) infection and the other related to other factors including phimosis, chronic inflammation, and lichen sclerosus. HPV DNA is found in 47% to 48% of all penile tumors, and most of these cases correspond to high-risk genotypes, preferentially HPV-16. HPV status is associated with histologic subtype, with higher detection ratios in warty-basaloid carcinomas and lower detection ratios in keratinizing variants (ie, verrucous, papillary, and usual squamous cell carcinomas). It is the cell type, rather than a distinctive architecture, that is more strongly associated with HPV presence. The detection ratio is higher in tumors composed entirely or partially of cells with basaloid features. In addition, a few studies have evaluated the impact of HPV infection on the prognosis of patients with penile cancer. However, results are controversial, and more data are needed to clarify this matter. A proper understanding of the role of HPV in penile carcinogenesis might help in planning intervention strategies such as vaccination against HPV infection. (C) 2012 Elsevier Inc. All rights reserved.
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