Journal
SEMINARS IN DIAGNOSTIC PATHOLOGY
Volume 28, Issue 2, Pages 167-177Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.semdp.2011.04.001
Keywords
DLBCL; Genetic lesions; Germinal center
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Funding
- NCI NIH HHS [R37 CA037295] Funding Source: Medline
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In past years, substantial insight regarding the pathogenesis of diffuse large B-cell lymphoma has been obtained. Particularly, based on gene expression profile analysis, this disease can be classified into distinct phenotypic subgroups and specific transcriptional programs have been identified. New technologies like next-generation whole genome/exome sequencing and genome-wide single nucleotide polymorphism array analysis have revealed novel lesions involved in the pathogenesis of this disease. This review focuses on the diversity of genetic lesions identified in the different subtypes of diffuse large B-cell lymphoma. (C) 2011 Elsevier Inc. All rights reserved.
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