Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 34, Issue -, Pages 24-32Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2014.05.018
Keywords
Deadenylation; Poly(A) tail; Polyadenylation; Hyperadenylation; mRNA 3 ' end processing
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Funding
- NIH [GM072481]
- NSF [MCB-1301983]
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While the phenomenon of polyadenylation has been well-studied, the dynamics of poly(A) tail size and its impact on transcript function and cell biology are less well-appreciated. The goal of this review is to encourage readers to view the poly(A) tail as a dynamic, changeable aspect of a transcript rather than a simple static entity that marks the 3' end of an mRNA. This could open up new angles of regulation in the post-transcriptional control of gene expression throughout development, differentiation and cancer. (C) 2014 Elsevier Ltd. All rights reserved.
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