Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 33, Issue -, Pages 81-92Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2014.05.007
Keywords
Non-canonical Hedgehog signalling; Metabolism; Development; Cancer
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Funding
- Austrian Science Fund FWF [P 20652, P 25629] Funding Source: Medline
- NIGMS NIH HHS [R01 GM088256] Funding Source: Medline
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Obesity and diabetes represent key healthcare challenges of our day, affecting upwards of one billion people worldwide. These individuals are at higher risk for cancer, stroke, blindness, heart and cardiovascular disease, and to date, have no effective long-term treatment options available. Recent and accumulating evidence has implicated the developmental morphogen Hedgehog and its downstream signalling in metabolic control. Generally thought to be quiescent in adults, Hedgehog is associated with several human cancers, and as such, has already emerged as a therapeutic target in oncology. Here, we attempt to give a comprehensive overview of the key signalling events associated with both canonical and non-canonical Hedgehog signalling, and highlight the increasingly complex regulatory modalities that appear to link Hedgehog and control metabolism. We highlight these key findings and discuss their impact for therapeutic development, cancer and metabolic disease. (C) 2014 Elsevier Ltd. All rights reserved.
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