Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 36, Issue -, Pages 224-231Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2014.09.008
Keywords
Tight junction; Tumour; Metastasis
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Funding
- Cancer Research Wales
- Cardiff-China Medical Research Collaborative
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Over the last decade, it has become apparent that the tight junction (TJ) is a key component in tumour progression and metastasis. In addition to its role in the control of paracellular diffusion of ions and certain molecules, the TJ has a vital role in maintaining cell to cell adhesion and tissue integrity. Changes in the expression and/or distribution of TJ proteins can result in loss in cohesion of the TJ structure, which in turn results in the ability of cancer cells to become invasive and then ultimately lead to the metastasis of cancer cells. This review will discuss recent insights into how TJ are involved in the process of tumour metastasis. (C) 2014 Elsevier Ltd. All rights reserved.
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