Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 32, Issue -, Pages 30-36Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2014.03.016
Keywords
Alternative splicing; Signal transduction; Epithelial to mesenchymal transition; Epigenetic; Splicing factors
Categories
Funding
- Associazione Italiana per la Ricerca sul Cancro (AIRC) [IG-11492, MFAG 11913]
- Association for International Cancer Research (AICR-UK) [11-0622]
- Flagship project Epigen CNR-MIUR
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Alternative splicing emerges as a potent and pervasive mechanism of gene expression regulation that expands the coding capacity of the genome and forms an intermediate layer of regulation between transcriptional and post-translational networks. Indeed, alternative splicing occupies a pivotal position in developmental programs and in the cell response to external and internal stimuli. Not surprisingly, therefore, its deregulation frequently leads to human disease. In this review we provide an updated overview of the impact of alternative splicing on tumorigenesis. Moreover, we discuss the intricacy of the reciprocal interactions between alternative splicing programs and signal transduction pathways, which appear to be crucially linked to cancer progression in response to the tumor microenvironment. Finally, we focus on the recently described interplay between splicing and chromatin organization which is expected to shed new lights into gene expression regulation in normal and cancer cells. (C) 2014 Elsevier Ltd. All rights reserved.
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