Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 28, Issue -, Pages 2-11Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2014.01.011
Keywords
Epidermal growth factor; Expression; Cell proliferation; Regeneration; Ion transport; Cancer
Categories
Funding
- National Institutes of Health [DK038226, DK051265, DK062794, DK095785]
- Department of Veterans Affairs
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In 1962, epidermal growth factor (EGF) was discovered by Dr. Stanley Cohen while studying nerve growth factor (NGF). It was soon recognized that EGF is the prototypical member of a family of peptide growth factors that activate the EGF receptors, and that the EGF/EGF receptor signaling pathway plays important roles in proliferation, differentiation and migration of a variety of cell types, especially in epithelial cells. After the basic characterization of EGF function in the first decade or so after its discovery, the studies related to EGF and its signaling pathway have extended to a broad range of investigations concerning its biological and pathophysiological roles in development and in human diseases. In this review, we briefly describe the gene organization and tissue distribution of EGF, with emphasis on its biological and pathological roles in human diseases. (C) 2014 Elsevier Ltd. All rights reserved.
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