Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 35, Issue -, Pages 180-188Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2014.07.012
Keywords
Olfactory bulb; Glomerulus; Lateral inhibition; Temporal coding; Development; Plasticity
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Funding
- PRESTO program-of the Japan Science and Technology Agency, JSPS KAKENHI [23680038]
- Mitsubishi Foundation
- RIKEN Center for Developmental Biology
- Grants-in-Aid for Scientific Research [23680038] Funding Source: KAKEN
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Recent studies using molecular genetics, electrophysiology, in vivo imaging, and behavioral analyses have elucidated detailed connectivity and function of the mammalian olfactory circuits. The olfactory bulb is the first relay station of olfactory perception in the brain, but it is more than a simple relay: olfactory information is dynamically tuned by local olfactory bulb circuits and converted to spatiotemporal neural code for higher-order information processing. Because the olfactory bulb processes 1000 discrete input channels from different odorant receptors, it serves as a good model to study neuronal wiring specificity, from both functional and developmental aspects. This review summarizes our current understanding of the olfactory bulb circuitry from functional standpoint and discusses important future studies with particular focus on its development and plasticity. (C) 2014 The Authors. Published by Elsevier Ltd.
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