Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 24, Issue 3, Pages 163-171Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2012.09.008
Keywords
Semaphorin; Bone remodeling; Osteopetrosis; Osteoporosis
Categories
Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Ministry of Health, Labour, and Welfare
- Funding Program for Next-Generation World-Leading Researchers (NEXT Program)
- Special Coordination Funds for Promoting Science and Technology
- Core Research for Evolutional Science and Technology (CREST) Program of the Japan Science and Technology Agency
Ask authors/readers for more resources
Semaphorins were originally identified as axon guidance cues in the development of the nervous system. In recent years, numerous studies have determined that they are also involved in organogenesis, vascularization/angiogenesis, oncogenesis, and immune responses. In addition, the mechanisms underlying the diverse functions of semaphorins and their receptors have been identified. Recently, significant advances have been made in our understanding of the roles of semaphorins in bone remodeling, particularly the regulation of osteoclast and osteoblast differentiation and migration. Moreover, dysregulated semaphorin expression causes severe bone diseases, including osteoporosis and osteopetrosis. This review focuses on advanced findings on the role of semaphorins/receptors and their intracellular signaling in the regulation of bone homeostasis. (C) 2012 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available