Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 24, Issue 1, Pages 40-50Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2012.09.003
Keywords
Oxygen sensing; CO2/H+ sensing; Mechanosensing; O-2 sensitive K+ channels; NADPH oxidase; Vagal afferents
Categories
Funding
- Canadian Institutes for Health Research [MOP-15270, MOP-81211]
- Natural Sciences and Engineering Research Council
- Canadian Cystic Fibrosis Foundation
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Pulmonary neuroepithelial bodies are polymodal sensors widely distributed within the airway mucosa of mammals and other species. Neuroepithelial body cells store and most likely release serotonin and peptides as transmitters. Neuroepithelial bodies have a complex innervation that includes vagal sensory afferent fibers and dorsal root ganglion fibers. Neuroepithelial body cells respond to a number of intraluminal airway stimuli, including hypoxia, hypercarbia, and mechanical stretch. This article reviews recent findings in the cellular and molecular biology of neuroepithelial body cells and their potential role as airway sensors involved in the control of respiration, particularly during the perinatal period. Alternate hypotheses and areas of controversy regarding potential function as mechanosensory receptors involved in pulmonary reflexes are discussed. (C) 2012 Elsevier Ltd. All rights reserved.
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