Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 24, Issue 5, Pages 422-429Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2013.03.006
Keywords
Circadian clocks; Natural variation; QTL; Arabidopsis; Adaptive
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Funding
- Max Planck Society
- Deutsche Forschungsgemeinschaft [DA1061/4-1, DA1061/5-1 SPP1530, DA1061/6-1 SFB635, DA1061/7-1]
- HEC-DAAD program
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Circadian clocks are ubiquitous mechanisms that provide an adaptive advantage by predicting subsequent environmental changes. In the model plant Arabidopsis thaliana (Arabidopsis), our understanding of the complex genetic network among clock components has considerably increased during these past years. Modeling has predicted the possibility of additional component to systematically and functionally complete the clock system. Mutagenesis screens have in the past been successfully employed to detect such novel components. With the advancement in sequencing technologies and improvements in statistical approaches, the extensive natural variation present in Arabidopsis accessions has emerged as a powerful alternative in functional gene discovery. In this review article, we review the previous efforts in mapping natural alleles affecting various clock parameters and will discuss further potentials of such natural-variation studies in physiological and ecological contexts. (C) 2013 Elsevier Ltd. All rights reserved.
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