Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 24, Issue 1, Pages 51-57Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2012.09.002
Keywords
Review; TRPV1; Pain; 5-HT; Serotonin; Nociception
Categories
Funding
- NCATS NIH HHS [UL1 TR001120] Funding Source: Medline
- NIDCR NIH HHS [R01 DE015576, F32 DE021309] Funding Source: Medline
- NINDS NIH HHS [R01 NS058655] Funding Source: Medline
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Nociception, the encoding and processing of noxious environmental stimuli by sensory neurons, functions to protect an organism from bodily damage. Activation of the terminal endings of certain sensory neurons, termed nociceptors, triggers a train of impulses to neurons in the spinal cord. Signals are integrated and processed in the dorsal spinal cord and then projected to the brain where they elicit the perception of pain. A number of neuromodulators that can affect nociceptors are released in the periphery during the inflammation that follows an initial injury. Serotonin (5-HT) is a one such proinflammatory mediator. This review discusses our current understanding of the neuromodulatory role of 5-HT, and specifically how this monoamine activates and sensitizes nociceptors. Potential therapeutic targets to treat pain are described. Published by Elsevier Ltd.
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