Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 23, Issue 7, Pages 794-802Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2012.04.001
Keywords
Cell cycle; Kinase signalling; MST, NDR/STK38 and LATS kinases; MOB proteins, Phosphorylation
Categories
Funding
- Wellcome Trust [090090/Z/09/Z]
- Wellcome Trust [090090/Z/09/Z] Funding Source: Wellcome Trust
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Over the past decade Hippo kinase signalling has been established as an essential tumour suppressor pathway controlling tissue growth in flies and mammals. All members of the Hippo core signalling cassette are conserved from yeast to humans, whereby the yeast analogues of Hippo, Mats and Lats are central components of the mitotic exit network and septation initiation network in budding and fission yeast, respectively. Here, we discuss how far core Hippo signalling components in Drosophila melanogaster and mammals have reported similar mitotic functions as already established for their highly conserved yeast counterparts. (C) 2012 Published by Elsevier Ltd.
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