Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 23, Issue 2, Pages 237-242Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2011.12.008
Keywords
Next-generation sequencing; Metastasis; Clonal evolution; High throughput
Categories
Funding
- National Institutes of Health [CA140599, P50 CA62924]
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Cancer is a disease caused by the accumulation of genetic alterations in association with successive waves of clonal expansion. Mapping of the human genome sequence, in conjunction with technical advances in the ability to sequence entire genomes, have provided new insight into the mutational spectra and genetic events associated with clonal evolution of cancer. Moving forward, a clearer understanding of those alterations that undergo positive and negative selection throughout carcinogenesis and leading to metastatic dissemination would provide a boon not only to our understanding of cancer evolution, but to the development of potential targets for therapeutic intervention as well. (C) 2012 Elsevier Ltd. All rights reserved.
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