Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 23, Issue 8, Pages 890-896Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2012.08.008
Keywords
Epidermis; Polarity; Asymmetric cell division; Cell adhesion; Mitotic spindle
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Funding
- [NIH-R01AR055926]
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Polarity is a fundamental property of epithelial cells. In this review, we discuss our current knowledge of the polarity of a stratified epithelium, the epidermis, focusing on similarities and differences with simple epithelial models. We highlight how the differences in tissue architecture and physiology result in alterations in some aspects of cell polarity. In addition, we discuss one of the most prominent uses for cell polarity in the epidermis-orienting the mitotic spindle to drive the stratification and differentiation of this tissue during development. (C) 2012 Elsevier Ltd. All rights reserved.
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