Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 22, Issue 2, Pages 214-219Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2011.02.009
Keywords
ATP release; Neuron-glia interactions; Axon volume; Intrinsic optical signals; Activity-dependent development; Synaptic-vesicle release; Neurotransmitter release; Axon swelling; Learning; Volume-activated anion channel; White matter
Categories
Funding
- National Institutes of Child Health
- Human Development funds for intramural research
Ask authors/readers for more resources
Studies on the release of ATP from neurons began with the earliest investigations of quantal neurotransmitter release in the 1950s, but in contrast to ATP release from other cells, studies of ATP release from neurons have been narrowly constrained to one mechanism, vesicular release. This is a consequence of the prominence of synaptic transmission in neuronal communication, but nonvesicular mechanisms for ATP release from neurons are likely to have a broader range of functions than synaptic release. Investigations of activity-dependent communication between axons and myelinating glia have stimulated a search for mechanisms that could release ATP from axons and other nonsynaptic regions in response to action potential firing. This has identified volume-activated anion channels as an important mechanism in activity-dependent ATP release from axons, and renewed interest in micromechanical changes in axons that accompany action potential firing. (C) 2011 Published by Elsevier Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available