Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 22, Issue 2, Pages 153-159Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2010.09.009
Keywords
Mass spectrometry; Phosphoproteomics; VGSC (Nav channel); VGKC (Kv channel); Brain ion channel
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Funding
- NIH [NS38343, NS42225, NS64428, NS64957]
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Voltage-gated sodium and potassium channels underlie electrical activity of neurons, and are dynamically regulated by diverse cell signaling pathways that ultimately exert their effects by altering the phosphorylation state of channel subunits. Recent mass spectrometric-based studies have led to a new appreciation of the extent and nature of phosphorylation of these ion channels in mammalian brain. This has allowed for new insights into how neurons dynamically regulate the localization, activity and expression through multisite ion channel phosphorylation. (C) 2010 Elsevier Ltd. All rights reserved.
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