Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 22, Issue 2, Pages 160-165Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2010.10.002
Keywords
Sodium channels; Phosphorylation; Kinase; Neurotransmitter; Phosphatase; Ion channels
Categories
Funding
- National Institutes of Health [NS64428]
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Voltage-gated sodium channels carry the major inward current responsible for action potential depolarization in excitable cells as well as providing additional inward current that modulates overall excitability. Both their expression and function is under tight control of protein phosphorylation by specific kinases and phosphatases and this control is particular to each type of sodium channel. This article examines the impact and mechanism of phosphorylation for isoforms where it has been studied in detail in an attempt to delineate common features as well as differences. (C) 2010 Elsevier Ltd. All rights reserved.
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