Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 22, Issue 9, Pages 916-926Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2011.09.014
Keywords
Tubulin; FtsZ; Taxol; Vinblastine; Dynamic instability
Categories
Funding
- Medical Research Council [MC_U105184313] Funding Source: Medline
- MRC [MC_U105184313] Funding Source: UKRI
- Medical Research Council [MC_U105184313] Funding Source: researchfish
Ask authors/readers for more resources
A wide range of small molecules, including alkaloids, macrolides and peptides, bind to tubulin and disturb microtubule assembly dynamics. Some agents inhibit assembly, others inhibit disassembly. The binding sites of drugs that stabilize microtubules are discussed in relation to the properties of microtubule associated proteins. The activities of assembly inhibitors are discussed in relation to different nucleotide states of tubulin family protein structures. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available