Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 22, Issue 8, Pages 906-912Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2011.07.001
Keywords
BLM; Bloom's syndrome; Fanconi anemia; PICH; Anaphase bridges; Chromosome segregation
Categories
Funding
- Nordea Foundation
- Danish Cancer Society
- Association for International Cancer Research
- Worldwide Cancer Research [10-0500] Funding Source: researchfish
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Recent data indicate an unexpected requirement for proteins that were hitherto considered to be dedicated to DNA repair to facilitate the faithful disjunction of sister chromatids in anaphase. These include the Bloom's syndrome gene product, BLM and its partners, as well as a number of proteins that are important for preventing Fanconi anemia (FA) in man. As part of an analysis of the roles of these proteins in mitosis, we identified a novel class of anaphase bridge structure, called an ultra-fine anaphase bridge (UFB). These UFBs are also defined by the presence of a SNF2 family protein called PICH. In this review, we will discuss the possible sources of UFBs, and how the BLM, PICH and FA proteins might serve to process these structures in order to maintain genome stability. (C) 2011 Elsevier Ltd. All rights reserved.
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