4.6 Review

Neuronal polarization and the cytoskeleton

Journal

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 22, Issue 8, Pages 825-833

Publisher

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2011.08.007

Keywords

Neuronal polarization; Axon formation; Actin cytoskeleton; Microtubules; Plus end tracking; Proteins

Funding

  1. Max Planck Society
  2. Deutsche Forschungsgemeinschaft
  3. Human Frontier Science Program

Ask authors/readers for more resources

Neuronal polarization, the formation of one long axon and several short dendrites, is an obligatory process to integrate and propagate information within the brain. Axon formation is the key event during neuronal polarization and is based on tightly regulated rearrangements of the cytoskeleton. Here, we discuss how the cytoskeleton drives neuronal polarization. First, we convey the role of the actin cytoskeleton and microtubules during axon formation. Second, we discuss different cytoskeletal binding and regulating proteins, which are essential to specify the axon. Finally, we outline plus end tracking proteins (+TIPs) as important regulators for neuronal polarization by mediating the interaction between the actin cytoskeleton and microtubules and compare this function to other polarity processes. (C) 2011 Elsevier Ltd. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available