Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 22, Issue 9, Pages 1012-1018Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2011.10.005
Keywords
Bone Morphogenetic Protein; Angiogenesis; Pulmonary arterial hypertension
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Funding
- NHLBI NIH HHS [R01 HL090960-04, R01 HL090960, R01 HL090960-04S1] Funding Source: Medline
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Bone Morphogenetic Protein (BMP) signaling has been implicated in diverse biological processes. Although how BMP signaling regulates behaviors of endothelial cells during angiogenesis are not fully understood, increasing evidence indicate functions of BMP signaling components are essential in developmental and pathological angiogenesis. Here we review recent advances in delineating the functions of BMP signaling during angiogenesis. In addition, we discuss downstream pathways that transduce BMP signaling in endothelial cells, and factors that modulate BMP signaling response in endothelial cells. Finally, we provide recent insight on how BMP signaling functions as a context dependent angiogenic cue. (C) 2011 Elsevier Ltd. All rights reserved.
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