Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 22, Issue 9, Pages 976-984Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2011.09.009
Keywords
ETS; Endothelial; Gene expression; Development
Categories
Funding
- The Hartwell Foundation
- NIH [5-T32-HL007360-32, T32 GM08659]
- Bellows Foundation
- Sarver Heart Center
- NHLBI of the NIH [RO1 HL093694]
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The ETS family of transcription factors plays an essential role in controlling endothelial gene expression. Multiple members of the ETS family are expressed in the developing endothelium and evidence suggests that the proteins function, to some extent, redundantly. However, recent studies have demonstrated a crucial non-redundant role for ETV2, as a primary player in specification and differentiation of the endothelial lineage. Here, we review the contribution of ETS factors, and their partner proteins, to the regulation of embryonic vascular development. (C) 2011 Elsevier Ltd. All rights reserved.
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