Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 21, Issue 3, Pages 255-259Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2010.01.019
Keywords
Eg5; Mitosis; Spindle; Kinesin; Dynein
Categories
Funding
- NIGMS NIH HHS [R01 GM059057, R01 GM059057-08S1] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM059057] Funding Source: NIH RePORTER
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In all eukaryotic cells, molecular motor proteins play essential roles in spindle assembly and function. The homotetrameric kinesin-5 motors in particular generate outward forces that establish and maintain spindle bipolarity and contribute to microtubule flux. Cell-cycle dependent phosphorylation of kinesin-5 motors regulates their localization to the mitotic spindle. Analysis of live cells further shows that kinesin-5 motors are highly dynamic in the spindle. Understanding the interactions of kinesin-5 motors with microtubules and other spindle proteins is likely to broaden the documented roles of kinesin-5 motors during cell division. (C) 2010 Elsevier Ltd. All rights reserved.
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