Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 21, Issue 7, Pages 699-711Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2010.04.003
Keywords
Autophagy; Innate immunity
Categories
Funding
- Ellison Medical Foundation
- NIH [RO1 AI151367, T32 AI070116]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [T32AI070116] Funding Source: NIH RePORTER
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Autophagy is a conserved catabolic stress response pathway that is increasingly recognized as an important component of both innate and acquired immunity to pathogens. The activation of autophagy during infection not only provides cell-autonomous protection through lysosomal degradation of invading pathogens (xenophagy), but also regulates signaling by other innate immune pathways. This review will focus on recent advances in our understanding of three major areas of the interrelationship between autophagy and innate immunity, including how autophagy is triggered during infection, how invading pathogens are targeted to autophagosomes, and how the autophagy pathway participates in tuning the innate immune response. (C) 2010 Elsevier Ltd. All rights reserved.
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