Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 20, Issue 3, Pages 337-345Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2008.12.014
Keywords
Mitochondria; Calcium signaling; Heart development; NFAT; Nkx2-5
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Funding
- Agency for Science, Technology and Research of Singapore
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Calcium (Ca(2+)) is a simple but critical signal for controlling various cellular processes and is especially important in fertilization and embryonic development. The dynamic change of cellular Ca(2+) concentration and homeostasis are tightly regulated. Cellular Ca(2+) increases byway of Ca(2+) influx from extracellular medium and Ca(2+) release from cellular stores of the endoplasmic reticulum (ER) and sarcoplasmic reticulum (SR). The elevated Ca(2+) is subsequently sequestered by expelling it out of the cell or by pumping back to the ER/SR. Mitochondria function as a power house for energy production via oxidative phosphorylation in most eukaryotes. In addition to this well-known function, mitochondria are also recognized to regulate Ca(2+) homeostasis through different mechanisms. Although critical roles of Ca(2+) signaling in fertilization and embryonic development are known, the involvement of mitochondria in these processes are not fully understood. This review is focused on the role of mitochondrial respiratory chain complex I in the regulation of Ca(2+) signaling pathway and gene expression in embryonic development, especially on the new findings in the cardiac development of Xenopus embryos. The data demonstrate that mitochondria modulate Ca(2+) signaling and the Ca(2+)-dependent NFAT pathway and its target gene which are essential for embryonic heart development. (C) 2009 Elsevier Ltd. All rights reserved.
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